National Service Deferment

The Minister for Defence said that there was no preference treatment for National Service deferment. He explained in detail to Parliament how the process for deferment was carried out. However, the newspaper report did not carry the details. I hope that our MPs in Parliament would question the process, to ensure that the relevant questions have been asked and answered satisfactorily.

http://www.straitstimes.com/Parliament/Story/STIStory_725378.html

My preference is for National Service to be made fairer to male citizens, so that they do not need to sacrifice their time and opportunity. This can be done through reducing the duration of national service and/ or compensating them adequately for the time that they have to spend. The Singapore males have to compete with foreigners and females in the job market and should not be placed at a disadvantage.

List of contractors

The list of contractors have been updated to include plumbing, electrical and TV repair. There are now 13 categories of contractors. This list will be converted into a database for easy access at a later date. The contractors have been contacted to establish their responsiveness to calls or emails.
http://tankinlian.com/admin/file.aspx?id=579

Top-up CPF by cash

The charge (by eNETS) to top up a CPF by internet banking is too high. For an amount of $1,000, the charge is $15. For a larger amount, the charge is NOT specified.

To avoid this excessive charge, I decided to pay by cheque ($0.25 for postage). But I have to write a lot of detail at the bank of the cheque including an unweildly transaction number. See below.

This is not the only thing that I have to write. I still have to write the cheque and make sure that the amount in words and letters are correct, the date is correct, the payee is correct. I also have to make sure that the address of CPF is correctly written on the envelope.  This is a sad part of life in Singapore - so much hassle and over-charging.

Top-up CPF account

CPF took an advertisement to advice members to top-up their CPF account (for themselves and their family members). I responded and tried to do it at their website. My experience is shown in this report, which I sent to the Ministry of Manpower. My findings:

1. The CPF online process has bugs.
2. The administration charge is too high.

I hope that our Government will wake up and sort out the shortcomings and over-charging!

http://tankinlian.com/admin/file.aspx?id=581

I Did a Crazy Fad Diet From the Internet

Those Internet ads that say you can ?lose a pound a day with one simple trick?? The hCG diet is one that you?ll find when you click on those. And there is a trick to succeeding on the diet: Don?t follow the plans on the Internet, which usually involve ordering homeopathic drops. The FDA considers the drops to be ?fraudulent and illegal,? though the agency rarely does anything about it. Instead, find a doctor to prescribe injections. They are considered off-label use for weight loss, but when I found out that my OB-GYN?the same woman who once changed her vacation plans to deliver one of my kids?was offering the diet through her practice, I figured it was safe enough to consider. I attended an information session, learned the pros and the cons, and thought about it. And then I mentally deducted all the money from my imaginary iPad fund (It cost me $450, which isn?t cheap, but then, neither is Nutrisystem), and went for it.

Source: http://feeds.slate.com/click.phdo?i=6b1216eb99b45148b65ec5786f31a4c9

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X-linked mental retardation protein is found to mediate synaptic plasticity in hippocampus

X-linked mental retardation protein is found to mediate synaptic plasticity in hippocampus

Wednesday, October 19, 2011

Scientists at Cold Spring Harbor Laboratory (CSHL) have solved part of a puzzle concerning the relationship between changes in the strength of synapses ? the tiny gaps across which nerve cells in the brain communicate ? and dysfunctions in neural circuits that have been linked with drug addiction, mental retardation and other cognitive disorders.

A team led by CSHL Professor Linda Van Aelst has pieced together essential steps in a signaling cascade within excitatory nerve cells that explains a key phenomenon called longterm depression, or LTD. The "depression" in question has nothing to do with the human illness with that name. Rather, it refers to a tamping-down of the strength of individual synapses ? what scientists call synaptic plasticity.

The mechanism behind LTD is called endocytosis. It involves a retraction of receptors where neurotransmitters can "dock." Van Aelst and colleagues have demonstrated how LTD works following activation of a class of receptors called group I metabotrobic glutamate receptors, or mGluRs.

It was known that longterm depression mediated by mGluRs depended in part on the rapid synthesis of specific proteins. Yet the identity of these proteins had largely remained a mystery. The CSHL scientists have now shown that locally rapid production of a protein called oligophrenin 1 (OPHN1) follows activation of group I mGluRs. OPHN1 in turn was shown to mediate LTD in hippocampal nerve cells, by interacting with yet another protein called EndophilinA2/3.

The result of this cascade of intracellular signals was dramatic: persistent removal of AMPA-type receptors at the excitatory synapse, and the onset of LTD. When rapid production of OPHN1 was blocked, mGluR-dependent LTD did not occur. These findings appear online today ahead of print in the journal Neuron.

Van Aelst explained the significance of the finding. "OPHN1 has two important functions that we know about. One is early in development, after synapses have appeared in the emerging nervous system. In this phase, OPHN1 in concert with other factors stabilizes receptors at synapses, and thus is essential in maintaining the structure of these essential features of neural circuitry.

"Our new findings show another vital role for OPHN1, later in development and into maturity. We assume that in response to behavioral stimuli ? we aren't yet sure what kind ? mGluRs are activated, setting off the series of steps that we identified: rapid upregulation of OPHN1, which binds to EndophilinA2/3, which in turn mediates the long-term removal of AMPA receptors."

OPHN1 is known to be associated with X-linked mental retardation and with other cognitive and behavioral deficits. The team hypothesizes that OPHN1-related changes in plasticity such as those described in their new work may be causally related to such pathology. They are investigating this possibility in their current work.

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Cold Spring Harbor Laboratory: http://www.cshl.org

Thanks to Cold Spring Harbor Laboratory for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/114463/X_linked_mental_retardation_protein_is_found_to_mediate_synaptic_plasticity_in_hippocampus

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Large bonus to bankers

Goldman Sachs pays large bonuses to its employees, in spite of making a loss for its shareholders. The amount of bonus is described as "ridiculous". http://money.cnn.com/2011/10/20/news/economy/goldman_sachs_occupy_wall_street/index.htm?section=money_topstories&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fmoney_topstories+%28Top+Stories%29